Mechanism of Action

Mechanism of Action

Aggrastat® is a reversible antagonist of fibrinogen that binds to the glycoprotein(GP) IIb/IIIa receptor, thereby blocking the final common pathway to platelet aggregation.

Aggrastat is a reversible antagonist of fibrinogen that binds to the glycoprotein(GP) IIb/IIIa receptor, thereby blocking the final common pathway to platelet aggregation

Aggrastat® HDB achieves >90% platelet aggregation inhibition within 10 minutes.1,2

Aggrastat HDB achieves >90% platelet aggregation inhibition within 10 minutes.

  • Platelet inhibition is reversible following cessation of infusion
  • The half-life of the HDB regimen is 2 hours and platelet aggregation returns to normal within 4 - 8 hours in approximately 90% of patients

1. Mardikar HM et al. Am Heart J 2007; 154:344e1-344e5
2. Danzi GB et al. AM J Cardiol 2006; 97:489-493

IMPORTANT SAFETY INFORMATION

Indication:

Aggrastat® is indicated to reduce the rate of thrombotic cardiovascular events (combined endpoint of death, myocardial infarction, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).

Contraindications:

  • Known hypersensitivity to any component of Aggrastat®.
  • History of thrombocytopenia with prior exposure to Aggrastat®.
  • Active internal bleeding, or history of bleeding diathesis, major surgical procedure or severe physical trauma within the previous month.

Warnings and Precautions:

  • Aggrastat® can cause serious bleeding. Most bleeding associated with Aggrastat® occurs at the arterial access site for cardiac catheterization. Minimize the use of traumatic or potentially traumatic procedures such as arterial and venous punctures, intramuscular injections, nasotracheal intubation, etc. Concomitant use of fibrinolytics, anticoagulants and antiplatelet drugs increases the risk of bleeding. If bleeding cannot be controlled, discontinue Aggrastat®.
  • Thrombocytopenia: discontinue Aggrastat® and heparin.

Adverse Reactions:

  • Bleeding is the most commonly reported adverse reaction.

For additional information, refer to the full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.FDA.gov/medwatch
or call 1-800-FDA-1088.

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