Dosing and Administration

Dosing and Administration

High-Dose Bolus Regimen

High-Dose Bolus Regimen

Administer intravenously 25 mcg/kg within 5 minutes and then 0.15 mcg/kg/min for up to 18 hours. In patients with creatinine clearance (CrCl) ≤60 mL/min, give 25 mcg/kg bolus within 5 minutes followed by an infusion of 0.075 mcg/kg/min for up to 18 hours.

Administration

The following videos provide detailed instructions on how to use Aggrastat® High-Dose Bolus.

View now to see best practices for storing, dosing, and administering Aggrastat®.

Bolus Vial (250 mcg/mL)

Please see Important Safety information below and at the end of the video.

100 mL Vial / 250 mL Bag (50 mcg/mL Units)

Please see Important Safety information below and at the end of the video.

Drug Compatibilities

Aggrastat® can be administered in the same intravenous line as heparin, atropine sulfate, dobutamine, dopamine, epinephrine hydrochloride (HCl), famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride, and propranolol HCl. Do not administer Aggrastat® through the same IV line as diazepam. Do not add other drugs or remove solution directly from the Intravia bag with a syringe.

Instructions for Intravia Bags

To open, first tear off foil overpouch. Plastic may be opaque due to moisture absorption during sterilization, but will diminish gradually. Check for leaks by squeezing inner bag firmly. Discard if any leaks are found or the sterility is suspect. Do not use unless solution is clear and seal is intact. Do not use bags in series connections. Such use can result in air embolisms by drawing air from the first bag if it is empty of solution.

Instructions for 100 mL Vial

Ensure seal is intact. Remove vial cap. Place vial on a flat surface, insert a vented IV set and open the vent. Hang bottle by plastic hanger and adjust flow for appropriate dosing.

Dosing Formulas

Dosing Formulas

Dosing Calculator

Administration Options:
 Patient Weight (kg):
Creatinine Clearance:
  

Results
1. Bolus
(Using 250 mcg/mL Bolus Vial)
Volume (mL): 		2. Infusion
(Using 50 mcg/mL Units)
Rate (mL/hr):

Disclaimer

By using this resource, you agree to the following: This Dosing Calculator is being provided "AS IS" and is intended for use only by qualified healthcare providers. All calculations should be confirmed before use. Medicure makes no claims as to the accuracy of the information contained herein. The information being provided is not a substitute for clinical judgment. Neither Medicure, nor any other party involved in the preparation or publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance on this information.

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Important Safety Information  |  Prescribing Information
Important Safety Information  |  Prescribing Information

IMPORTANT SAFETY INFORMATION

Indication:

Aggrastat® is indicated to reduce the rate of thrombotic cardiovascular events (combined endpoint of death, myocardial infarction, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).

Contraindications:

  • Known hypersensitivity to any component of Aggrastat®.
  • History of thrombocytopenia with prior exposure to Aggrastat®.
  • Active internal bleeding, or history of bleeding diathesis, major surgical procedure or severe physical trauma within the previous month.

Warnings and Precautions:

  • Aggrastat® can cause serious bleeding. Most bleeding associated with Aggrastat® occurs at the arterial access site for cardiac catheterization. Minimize the use of traumatic or potentially traumatic procedures such as arterial and venous punctures, intramuscular injections, nasotracheal intubation, etc. Concomitant use of fibrinolytics, anticoagulants and antiplatelet drugs increases the risk of bleeding. If bleeding cannot be controlled, discontinue Aggrastat®.
  • Thrombocytopenia: discontinue Aggrastat® and heparin.

Adverse Reactions:

  • Bleeding is the most commonly reported adverse reaction.

For additional information, refer to the full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.FDA.gov/medwatch
or call 1-800-FDA-1088.

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