Dosing and Administration
High-Dose Bolus Regimen
Administer intravenously 25 mcg/kg within 5 minutes and then 0.15 mcg/kg/min for up to 18 hours. In patients with creatinine clearance (CrCl) ≤60 mL/min, give 25 mcg/kg bolus within 5 minutes followed by an infusion of 0.075 mcg/kg/min for up to 18 hours.
Administration
The following videos provide detailed instructions on how to use Aggrastat® High-Dose Bolus.
View now to see best practices for storing, dosing, and administering Aggrastat®.
Administration Using the Bolus Vial (250 mcg/mL) with 100 mL Vial (50 mcg/mL Units)
Please see Important Safety Information below and at the end of the video.
Administration Using the 100 mL Vial (50 mcg/mL Units)
Please see Important Safety Information below and at the end of the video.
Administration Using the 250 mL Bag (50 mcg/mL Units)
Please see Important Safety Information below and at the end of the video.
Drug Compatibilities
Aggrastat® can be administered in the same intravenous line as heparin, atropine sulfate, dobutamine, dopamine, epinephrine hydrochloride (HCl), famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride, and propranolol HCl. Do not administer Aggrastat® through the same IV line as diazepam. Do not add other drugs or remove solution directly from the bag with a syringe.
Instructions for Bags
To open the premixed bag, first tear off its foil overpouch. The plastic may be somewhat opaque because of moisture absorption during sterilization; the opacity will diminish gradually. Check for leaks by squeezing the inner bag firmly; if any leaks are found or sterility is suspect then the solution should be discarded. Do not use unless the solution is clear and the seal is intact.
Instructions for 100 mL Vial
Ensure seal is intact. Remove vial cap. Place vial on a flat surface, insert a vented IV set and open the vent. Hang bottle by plastic hanger and adjust flow for appropriate dosing.
Instructions for Calculating Creatinine Clearance
Please see Important Safety Information below and at the beginning of the video.
Dosing Formulas
Dosing Calculator
Disclaimer
By using this resource, you agree to the following: This Dosing Calculator is being provided "AS IS" and is intended for use only by qualified healthcare providers. All calculations should be confirmed before use. Medicure makes no claims as to the accuracy of the information contained herein. The information being provided is not a substitute for clinical judgment. Neither Medicure, nor any other party involved in the preparation or publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance on this information.