Dr. Deepak Talreja presents a case series on the contemporary use of glycoprotein IIb/IIIa inhibitors (GPIs).
The series is based on cases where patient treatment included Aggrastat (tirofiban hydrochloride) injection and is intended to be an educational resource for fellows and those who may not be familiar with the use of GPIs.
These cases and testimonials are based on the experiences of a few people. Not all cases are identical. You are not likely to have similar results.
Important Safety Information about the use of Aggrastat is provided below.
Clinical studies performance with Aggrastat are provided in the full Prescribing Information.
Dr. Deepak Talreja is an interventional cardiologist with Sentara Cardiology Specialists in Virginia Beach and Chesapeake. Dr. Talreja was integral in helping Sentara Heart Hospital develop its structural heart program. Here he presents three cases where he used Aggrastat in his practice:
A 62-year old male presents to the emergency department with lightheadedness, dyspnea, and diaphoresis with jaw aching. He was admitted. He had an initial normal troponin which later elevated to 59. He was diagnosed with ACS NSTEMI and taken to the cardiac catheterization lab. Upon examination, the right coronary artery (RCA) was occluded and could not be successfully wired. Watch to see how Dr. Talreja approached this case.
A 72-year old male who present to the hospital as an outpatient. He had a history of a history of coronary artery bypass grafting (CABG) times 3 two years prior. He now presents with new-onset unstable angina despite increasing guideline driven medical therapy (GDMT). See how Dr. Talreja approached this case and what he did next.
A patient presents to ED with non-specific ST changes with new T-wave inversions. His cardiac enzymes were positive suggestive of NSTEMI. His history was notable for previous coronary artery disease (CAD) with a prior ACS treated with a stent to the left anterior descending artery (LAD) and percutaneous transluminal coronary angioplasty (PTCA) of the first diagonal branch 2 years prior. Catheterizations showed occlusion of the mid LAD with collaterals partially filling the distal vessel. See how Dr. Talreja approached this case.
Aggrastat (tirofiban hydrochloride) is indicated to reduce the rate of thrombotic cardiovascular events (combined endpoint of death, myocardial infarction, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
* Concomitant use of fibrinolytic, anticoagulants and antiplatelet drugs increases the risk of bleeding.
Check out the experience of other healthcare providers in the US that use Aggrastat to reduce the rate of thrombotic complications for their patients during PCI.
Aggrastat® is indicated to reduce the rate of thrombotic cardiovascular events (combined endpoint of death, myocardial infarction, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).